Epigallocatechin-3-gallate preferentially induces aggregation of amyloidogenic immunoglobulin light chains
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چکیده
منابع مشابه
Epigallocatechin-3-gallate preferentially induces aggregation of amyloidogenic immunoglobulin light chains
Antibody light chain amyloidosis is a rare disease caused by fibril formation of secreted immunoglobulin light chains (LCs). The huge variety of antibody sequences puts a serious challenge to drug discovery. The green tea polyphenol epigallocatechin-3-gallate (EGCG) is known to interfere with fibril formation in general. Here we present solution- and solid-state NMR studies as well as MD simula...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/srep41515